There’re two things you should think about when reading the lie around the green when you’re in the rough. Think about speed and loft. Consider whether the ball is sitting down in some thick grass or whether it’s sitting up on top of the grass and then how speed and loft are going to affect those two lies.
When the ball is sitting down, take a high lofted wedge, open the face, and give it plenty of speed to get the ball out of the rough. When the ball is sitting on top, take a less lofted wedge, think about speed and loft, don’t open the face as much, and then take a slower swing. This is going to allow you to get solid contact without cutting underneath the ball and only hitting it just a little bit in front.